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© 2019, Springer Nature Switzerland AG. Histone demethylases (KDMs) catalyse the removal of N-methyl marks on histones and play important roles in epigenetic regulation. Abnormal histone methylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This chapter provides an overview of JmjC-domain-containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structural perspective.

Original publication

DOI

10.1007/7355_2019_75

Type

Chapter

Book title

Topics in Medicinal Chemistry

Publication Date

01/01/2020

Volume

33

Pages

221 - 253