An injectable cure for inherited heart muscle conditions that can kill young people in the prime of their lives could be available within a few years, after an international team of researchers, led by Oxford University’s Professor Hugh Watkins and Harvard University’s Professor Christine Seideman, were announced as the winners of the British Heart Foundation’s Big Beat Challenge.
The global award, at £30m, is one of the largest non-commercial grants ever given and presents a “once in a generation opportunity” to provide hope for families struck by these killer diseases.
The winning team, CureHeart, will seek to develop the first cures for inherited heart muscle diseases by pioneering revolutionary and ultra-precise gene therapy technologies that could edit or silence the faulty genes that cause these deadly conditions.
'The £30 million from the BHF’s Big Beat Challenge will give us the platform to turbo-charge our progress in finding a cure so the next generation of children diagnosed with genetic cardiomyopathies can live long, happy and productive lives,' said Professor Watkins, who is the British Heart Foundation Professor of Cardiovascular Medicine at Oxford University Radcliffe Department of Medicine.
Professor Keith Channon, Head of the Radcliffe Department of Medicine, said: 'I am delighted that the BHF have chosen the CureHeart team to deliver on this world-leading challenge. The Radcliffe Department of Medicine looks forward to supporting and fostering the collaborations between scientists and researchers from many disciplines who will be key to the success of the Cure Heart programme.'
The team, made up of world-leading scientists from the UK, US and Singapore, were selected by an International Advisory Panel chaired by Professor Sir Patrick Vallance, Chief Scientific Advisor to the UK Government.
Professor Gavin Screaton, Head of the Medical Sciences Division, University of Oxford commented: ‘This is an extraordinary opportunity for the CureHeart team to make a difference in the lives of so many patients across the world. We have a long history of multidisciplinary working here in the Medical Sciences Division, and pride ourselves in the many successes our scientists have had in translating their cutting-edge lab research into real life treatments. This work by Professor Watkins and the international CureHeart team exemplifies this ethic at its best and we are truly excited to see their progress.’
ONE IN 250 PEOPLE WORLDWIDE
Inherited heart muscle diseases can cause the heart to stop suddenly or cause progressive heart failure in young people. Every week in the UK, 12 people under the age of 35 die of an undiagnosed heart condition, very often caused by one of these inherited heart muscle diseases, also known as genetic cardiomyopathies. Around half of all heart transplants are needed because of cardiomyopathy and current treatments do not prevent the condition from progressing.
It’s estimated that one in 250 people worldwide - around 260,000 people in the UK - are affected by genetic cardiomyopathies, with a 50:50 risk they will pass their faulty genes on to each of their children. In many cases, multiple members of the same family will develop heart failure, need a heart transplant, or are lost to sudden cardiac death at a young age.
The team will take the revolutionary gene-editing technology of CRISPR to the next level by deploying ultra-precise techniques called base and prime editing in the heart for the first time. These ground-breaking approaches use ingenious molecules that act like tiny pencils to rewrite the single mutations that are buried within the DNA of heart cells in people with genetic cardiomyopathies.
They will focus this technology on two areas. First, where the faulty gene produces an abnormal protein in the pumping machinery of the heart, the team will aim to correct or silence the faulty gene by re-writing the single spelling mistakes or switching off the entire copy of the faulty gene.
Second, where the faulty gene does not produce enough protein for the heart muscle to work as it should, the team plan to increase the production of healthy heart muscle proteins by using genetic tools to correct the function of the faulty copy of the gene or to stimulate the normal copy of the gene.
The team have already proven that these approaches are successful in animals with cardiomyopathies and in human cells. They believe the therapies could be delivered through an injection in the arm that would stop progression and potentially cure those already living with genetic cardiomyopathies. It could also prevent the disease developing in family members who carry a faulty gene but have not yet developed the condition.
Dr Christine Seidman at Harvard University and co-lead of CureHeart, said: 'Acting on our mission will be a truly global effort. We’ve brought in pioneers in new, ultra-precise gene editing, and experts with the techniques to ensure we get our genetic tools straight into the heart safely. It’s because of our world-leading team from three different continents that our initial dream should become reality.'
Professor Sir Nilesh Samani, Medical Director at the British Heart Foundation, said: 'This is a defining moment for cardiovascular medicine. Not only could CureHeart be the creators of the first cure for inherited heart muscle diseases by tackling killer genes that run through family trees, it could also usher in a new era of precision cardiology. Once successful, the same gene editing innovations could be used to treat a whole range of common heart conditions where genetic faults play a major role. This would have a transformational impact and offer hope to the thousands of families worldwide affected by these devastating diseases.'
Sir Patrick Vallance, Chair of the BHF’s International Advisory Panel and Government Chief Scientific Adviser, said: 'CureHeart was selected in recognition of the boldness of its ambition, the scale of its potential benefit for patients with genetic heart muscle diseases and their families, and the excellence of the international team of participating researchers.'
Dr Charmaine Griffiths, Chief Executive of the British Heart Foundation, said: 'With the public’s support, the aim of the Big Beat Challenge was to move past incremental progress and make a giant leap in an important area of heart patient care. Creating the world’s first genetic cure for a heart disease would undoubtedly do this and has the potential to stop families losing loved ones without a moment’s notice to these cruel diseases. However, we need the continued backing of our supporters to turn science like this into a reality for the millions of people around the world living with heart disease.'