Vincenzo d'Angiolella's group in the Oncology Department discovered that cancer cells die much faster when lacking the ubiquitin ligase adaptor Cyclin F as they accumulate E2F1, whose unrestricted activity promotes catastrophic replication stress upon Chk1 mediated checkpoint inhibition. Daniel Ebnerand Benedikt Kessler from the TDI participated in this study.
Aberrant accumulation of E2F1 upon cyclin F loss promotes DNA damage upon Chk1 inhibition - a novel anti-cancer strategy
21 August 2019