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The town that breeds resistance to Malaria drugs

The town that breeds resistance to Malaria drugs

Posted 13/04/2018

 

Pailin, a small settlement nestling in tropical rainforest near Cambodia’s border with Thailand, lies at the heart of a region that has seen successive waves of resistance to malaria drugs arise in local people and then spread across the globe. As new waves of the disease threaten our health, worried scientists want to conduct a mass inoculation in a Cambodian region where new vaccines always seem to stop being effective

Female body shape gene may increase risk of type 2 diabetes

Female body shape gene may increase risk of type 2 diabetes

Posted 13/04/2018

A recent publication in Nature Genetics, examined the effect of a gene called KLF14. The researchers, including Prof Mark McCarthy found that genetic variations that control KLF14 have little impact on overall weight but they have a marked impact on where in the body any excess fat is stored. In women, versions of the gene that are result in fat being preferentially deposited around the hips, rather than around the abdomen, provide protection against diabetes.

 

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Recent Publications

Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy. Sci Rep, 8 (1), pp. 5549. Article

A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes. Clin Proteomics, 15 (1), pp. 14. Article

HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 32 (6), pp. 709-714. Article

Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects. J Int AIDS Soc, 20 (1), pp. 21171. Article

Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? Could a CD8+ T-Cell Vaccine Prevent Persistent HIV Infection? Cold Spring Harb Perspect Biol, pp. a029124-a029124. Article

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