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Novel cancer treatment resistance mechanism uncovered

Novel cancer treatment resistance mechanism uncovered

Posted 02/08/2018

BRCA1 deficiencies cause breast and ovarian cancer, rendering tumours hypersensitive to PARP inhibitors. Patient treatment can become ineffective due to emerging resistance mechanisms. Ross Chapman’s team at the Welcome Centre has uncovered a protein complex termed Shieldin that acts with 53BP1 to limit end resection at DNA double-strand breaks, which confers resistance to cancer treatment.

Sarah Bonham, Roman Fischer and Benedikt Kessler from the TDI were part of this study published in Nature.
 

Biomarker discovery for patients with malignant pleural effusion

Biomarker discovery for patients with malignant pleural effusion

Posted 15/06/2018

Ioannis Psallidas (Respiratory Medicine) and colleagues including members of the Target Discovery Institute  (TDI) (Benedikt Kessler / Roman Fischer) have developed a score that predicts risk of death for a common metastasis of patients with malignant pleural effusion. Four proteins with a significant role in survival have been discovered, leading the road for new disease treatment. The PROMISE study results have been published in Lancet Oncology.

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Recent Publications

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun, 9 (1), pp. 3137. Article

Complex interactions in soil-transmitted helminth co-infections from a cross-sectional study in Sri Lanka. Trans R Soc Trop Med Hyg. Article

Diagnosing risk factors alongside mass drug administration using serial diagnostic tests-which test first? Trans R Soc Trop Med Hyg, 112 (7), pp. 342-348. Article

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg Med Chem, 26 (11), pp. 2965-2972. Article

Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion. Sci Rep, 8 (1), pp. 8539. Article

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